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Year : 2011  |  Volume : 10  |  Issue : 1  |  Page : 14-18

Ozurdex®, a novel dexamethasone delivery system, for treatment of macular edema following retinal vein occlusion

1 Deptartment of Ophthalmology, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil
2 Department of Ophthalmic Clinical Research, Allergan, Inc.; Irvine, CA, USA

Correspondence Address:
MD PhD Rubens Belfort
Department of Ophthalmology Federal University of Sao Paulo Rua Botucatu 822 Sao Paulo, SP 04023-062
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Source of Support: None, Conflict of Interest: None

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Resumen El tratamiento efectivo del edema macular representa un desafío principalmente debido a la limitada accesibilidad de fármaco vítreo para establecer y mantener niveles terapéuticos a largo plazo. El implante intravítreo de dexametasona (implante DEX; Ozurdex®) es actualmente el único sistema de aplicación de fármaco ocular biodegradable aprobado por la Administración de Alimentos y Medicamentos de EE.UU. que proporciona liberación del fármaco a una tasa estable por hasta 6 meses en el vítreo. Estudios clínicos recientes indican que el implante DEX emerge como una opción terapéutica efectiva y segura para el tratamiento de edema macular secundario a diversas enfermedades subyacentes. Abstract Effective treatment of macular edema is challenging primarily because of the limited vitreous drug accessibility to establish and maintain long-term therapeutic levels. Dexamethasone intravitreal implant (DEX implant; Ozurdex®) is currently the only biodegradable ocular drug delivery system approved by the US Food and Drug Administration that provides sustained drug release at a stable rate for up to 6 months in the vitreous. Recent clinical studies indicate that DEX implant is emerging as an effective and safe therapeutic option for treatment of macular edema secondary to a variety of underlying diseases.

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