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Year : 2020  |  Volume : 2  |  Issue : 1  |  Page : 19

The clinical and histopathological features of patients with both uveal and cutaneous melanoma

1 Ocular Pathology and Translational Research Laboratory, MUHC–McGill University; Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, Canada
2 Ocular Pathology and Translational Research Laboratory, MUHC–McGill University, Montréal, Canada

Correspondence Address:
Dr. Anelise Savaris Dias
Department of Ocular Pathology, McGill University, 1001 Boul Decarie, Block E, E02.6217, Montreal, QC, H4A 3J1
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/PAJO.PAJO_23_20

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Introduction: It is unusual to have uveal and cutaneous melanoma in the same patient. It is challenging to differentiate between primary uveal melanoma (UM) and melanoma metastatic to the uvea. Objective: The aim of this study is to evaluate the characteristics of patients who presented with concurrent melanomas (primary or metastatic) of the skin and uveal tract. Materials and Methods: Eleven patients with both uveal and cutaneous melanomas were obtained from the McGill University Ocular Pathology Laboratory database. The characteristics included cell type, number of mitotic figures, presence of necrosis, the time interval between primary and secondary melanoma and the presence of metastasis in other organs. Results: Five patients presented with both primary uveal and primary cutaneous melanoma, three patients with UM metastatic to the skin, and three patients with cutaneous melanoma metastatic to the uvea. In all of our cases, there was a time difference between the appearance of cutaneous and UM in the same patient. Conclusion: Patients with two primary melanomas presented with spindle-cell type (uveal tumor), a Breslow index <1 mm, >7 years between tumors. Systemic disease was negative. Patients with metastasis from cutaneous melanoma to the eye and from ocular to the skin showed epithelioid cell type, a Breslow index >1.5 mm, <5 years between tumors and positive systemic disease.

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