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Table of Contents
ORIGINAL ARTICLE
Year : 2020  |  Volume : 2  |  Issue : 1  |  Page : 31

The prevalence of diabetes among male glaucoma patients


1 Department of Ophthalmology, SUNY Downstate Medical Center, New York, USA
2 Stony Brook Medical Center, Stony Brook, New York, USA

Date of Submission25-Jun-2020
Date of Decision08-Jul-2020
Date of Acceptance27-Jul-2020
Date of Web Publication20-Oct-2020

Correspondence Address:
Dr. Nataliya Antonova
450 Clarkson Avenue Brooklyn, NY 11203
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/PAJO.PAJO_31_20

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  Abstract 


Introduction: The purpose of this study was to examine the relationship between diabetes and glaucoma.
Methods: Consecutive 143 subjects with primary angle-closure glaucoma and 127 subjects with primary open-angle glaucoma (control) were studied retrospectively at an urban Veterans Administration Hospital. In addition to ocular examination findings, body mass index (BMI) and diabetes mellitus (DM) status were recorded.
Results: All subjects in this study were male. The mean age was 72.3 years old in primary open angle versus 71.1 in primary angle-closure subjects. Half of the subjects with angle closure and 70% of open-angle subjects were self-identified as African–American. BMI was not significantly different between the two groups (28.2 in open angle vs. 28.7 in angle closure; P = 0.45). The percentage of DM was higher in subjects with primary angle closure than in those with primary open-angle glaucoma (43% vs. 29%, P = 0.001; Chi-square test). The odds of having DM were nearly two times higher in angle-closure subjects than open-angle subjects (Logistic regression, P = 0.01, 95% confidence interval: 1.17–3.30).
Conclusion: In this retrospective study, diabetes was found to be associated with higher risk for primary angle-closure glaucoma.

Keywords: Angle-closure glaucoma, diabetes, open-angle glaucoma


How to cite this article:
Antonova N, Dersu II, Burstein E, Lyons L, Hou W. The prevalence of diabetes among male glaucoma patients. Pan Am J Ophthalmol 2020;2:31

How to cite this URL:
Antonova N, Dersu II, Burstein E, Lyons L, Hou W. The prevalence of diabetes among male glaucoma patients. Pan Am J Ophthalmol [serial online] 2020 [cited 2020 Nov 27];2:31. Available from: https://www.thepajo.org/text.asp?2020/2/1/31/298636




  Introduction Top


More than 60 million people worldwide were estimated to have glaucoma in 2014 with the projection of reaching 111.8 million by 2040.[1] The numbers among Asian and African descent are particularly on the rise.[1] Many risk factors have been contributed to the glaucoma. In Rotterdam study, positive family history and high intraocular pressure (IOP) appeared to be risk factors for developing open-angle glaucoma during the two decades of observational study, while body mass index (BMI), gender, or myopia did not seem correlated.[2] Systemic conditions including obesity and diabetes were reported in various studies as contributing factors for open-angle glaucoma.[3],[4],[5],[6] The relationship between diabetes and angle-closure glaucoma is lesser known. In one large population study conducted in Asia where angle-closure glaucoma is more common than open angle, diabetes along with increasing age and female gender is described as risk factor.[7]

This study was undertaken to investigate the role of diabetes among male subjects with known glaucoma.


  Methods Top


This study was approved by the Veterans Administration New York Harbor Institutional Review Board and the ethical guidelines were followed. Subjects were chosen from a convenience sample from laser procedure records in the eye clinic. Subjects who underwent laser trabeculoplasty formed open-angle group (control) versus subjects who received laser iridotomy included in angle-closure group. The absence of visualization of 180° or more of pigmented trabecular meshwork with or without synechia qualified the subject for prophylactic laser iridotomy. Subjects who had mixed mechanism glaucoma or previous cataract surgery were excluded.

Data including BMI and the presence of diabetes were collected from the electronic health record. BMI was automatically calculated by the electronic medical records system using the last available data points for height and weight. Only Type II diabetes mellitus (DM) patients were included in this study.


  Results Top


Of 269 subjects, 127 had primary open-angle glaucoma and 142 had primary angle-closure glaucoma. Angle-closure subjects consisted of 80 African–American, 57 Caucasians, and 5 other races. There were 86 African–American, 39 Caucasians, and 2 other races in open-angle group. The mean age was 71.1 (35–92) for primary angle-closure group and 72.3 (41–93) was primary open-angle glaucoma group.

BMI was found to be similar in both the groups (28.2 in open angle vs. 28.7 in angle closure, P = 0.45). Percentage of diabetes was higher in primary angle-closure group than in primary open-angle group (43% vs. 29%, P = 0.001, Chi-square test). Based on the logistic regression, the odds of having diabetes were 1.97 times more likely in primary angle closure than the odds in open angle, 95% confidence interval [CI]: 1.17–3.30, P = 0.01 [Table 1]. Diabetic retinopathy was observed in 20% of diabetic patients in both glaucoma groups.
Table 1: Frequency and percentage of diabetes mellitus by glaucoma type

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  Discussion Top


Glaucoma is an optic neuropathy with two studied major mechanisms, one mechanical stress from increased IOP and second being reduced ocular perfusion pressure from variety of local and systemic conditions. The interaction between systemic comorbidities such as obesity, diabetes, hyperlipidemia, hypertension, and glaucoma has been area of interest to researchers in search of reducing the burden of the disease by risk modifications and alternative treatments. Obesity has been previously associated with increased IOP due to elevated episcleral venous pressure and consequently reduction in the outflow.[8] Diabetes is reported as a risk factor for angle closure in a Taiwanese population-based study, but interestingly, this finding was statistically significant only among males but not females.[9] In agreement with previous study, there was higher percentage of diabetes in the primary angle-closure subjects compared to primary open-angle subjects (43% vs. 29%, P = 0.001; odds ratio [OR] of 1.97) in this study. In addition, this study is also consistent with the outcome of research conducted in the Indian population where the presence of diabetes was reported significantly associated with increased angle-closure risk (OR: 3.18, 95% CI: 1.34–7.58, P = 0.001).[7] Furthermore, Saw et al.'s study among Singapore Chinese population (n = 943) found that subjects with self-claimed diabetes had increased risk of angle closure because of thicker lenses and shorter anterior chamber measured by A-mode ultrasound.[10] In addition to the aforementioned biometric changes, in postmortem eyes, age-related stiffening of scleral matrix has been reported to be accelerated in diabetic eyes.[11] Another factor to consider in angle-closure glaucoma patients is the choroidal thickness. There is mounting evidence that anterior choroid is thicker in primary angle-closure glaucoma than control subjects.[12],[13]

Subjects with diabetes usually require pharmacologically dilated eye examinations more often than ones without diabetes. Although the studies point to very low incidence of acute angle-closure glaucoma attack upon dilating diabetic patients, it may be important to identify subjects with angle closure because the condition may cause a detrimental effect on eye pressure and optic nerve health in long term.[14] Therefore, based on our finding of a higher prevalence of angle closure among diabetic subjects, it is recommended that eye examination in diabetic subjects should be used for the opportunity to screen for angle closure in addition to diabetic retinopathy.

Limitations of this study include, first, the study population included only males, second, subjects were part of a convenience sample who underwent laser, and third, subjects had access to comprehensive health care; therefore, the diagnosis of diabetes may have been understated in a different population.

The strength of the study is diabetes diagnosis which was instituted by a health-care provider rather than being self-claimed; second, as angle-closure glaucoma is more common in females, less information is known in the male population and this study sheds the light on male population.


  Conclusion Top


Diabetes appears to be an independent risk factor for primary angle-closure glaucoma.

It may be advisable to utilize gonioscopic examination more often to assess the angle during the diabetic eye examination.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis. Ophthalmology 2014;121:2081-90.  Back to cited text no. 1
    
2.
Springelkamp H, Wolfs RC, Ramdas WD, Hofman A, Vingerling JR, Klaver CC, et al. Incidence of glaucomatous visual field loss after two decades of follow-up: The Rotterdam study. Eur J Epidemiol 2017;32:691-9.  Back to cited text no. 2
    
3.
Cohen E, Kramer M, Shochat T, Goldberg E, Garty M, Krause I. Relationship between body mass index and intraocular pressure in men and women: A population-based study. J Glaucoma 2016;25:e509-13.  Back to cited text no. 3
    
4.
Prince J, Geberer N, Yao WJ, Katz B. The relationship of body mass index (BMI) to glaucoma. Invest Ophthalmol Vis Sci 2013;54:3510.  Back to cited text no. 4
    
5.
Zhou M, Wang W, Huang W, Zhang X. Diabetes mellitus as a risk factor for open-angle glaucoma: A systematic review and meta-analysis. PLoS One 2014;9:e102972.  Back to cited text no. 5
    
6.
Zhao D, Cho J, Kim MH, Friedman DS, Guallar E. Diabetes, fasting glucose, and the risk of glaucoma: A meta-analysis. Ophthalmology 2015;122:72-8.  Back to cited text no. 6
    
7.
Senthil S, Garudadri C, Khanna RC, Sannapaneni K. Angle closure in the Andhra Pradesh Eye Disease Study. Ophthalmology 2010;117:1729-35.  Back to cited text no. 7
    
8.
Cheung N, Wong TY. Obesity and eye diseases. Surv Ophthalmol 2007;52:180-95.  Back to cited text no. 8
    
9.
Chen HY, Lin CL. Comparison of medical comorbidity between patients with primary angle-closure glaucoma and a control cohort: A population-based study from Taiwan. BMJ Open 2019;9:e024209.  Back to cited text no. 9
    
10.
Saw SM, Wong TY, Ting S, Foong AW, Foster PJ. The relationship between anterior chamber depth and the presence of diabetes in the Tanjong Pagar Survey. Am J Ophthalmol 2007;144:325-6.  Back to cited text no. 10
    
11.
Coudrillier B, Pijanka J, Jefferys J, Sorensen T, Quigley HA, Boote C, et al. Effects of age and diabetes on scleral stiffness. J Biomech Eng 2015;137:071007.  Back to cited text no. 11
    
12.
Arora KS, Jefferys JL, Maul EA, Quigley HA. The choroid is thicker in angle closure than in open angle and control eyes. Invest Ophthalmol Vis Sci 2012;53:7813-8.  Back to cited text no. 12
    
13.
Huang W, Wang W, Gao X, Li X, Li Z, Zhou M, et al. Choroidal thickness in the subtypes of angle closure: An EDI-OCT study. Invest Ophthalmol Vis Sci 2013;54:7849.  Back to cited text no. 13
    
14.
Patel KH, Javitt JC, Tielsch JM, Street DA, Katz J, Quigley HA, et al. Incidence of acute angle-closure glaucoma after pharmacologic mydriasis. Am J Ophthalmol 1995;120:709-17.  Back to cited text no. 14
    



 
 
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