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REVIEW ARTICLE
Year : 2020  |  Volume : 2  |  Issue : 1  |  Page : 36

Use of topical tacrolimus in ophthalmology: Nonsystematic review


1 Department of Ophthalmology, Paulista Ophthalmology Unit – UPO, São Paulo, Brazil
2 Department of Ophthalmology, Paulista Ophthalmology Unit – UPO, São Paulo; Department of Ophthalmology, Sorocaba Eye Banking, Banco de Olhos de Sorocaba – BOS, Sorocaba, Brazil
3 Department of Ophthalmology, Paulista Ophthalmology Unit – UPO; Department of Visual Sciences, Federal University of São Paulo, UNIFESP, São Paulo, Brazil
4 Department of Visual Sciences, Federal University of São Paulo, UNIFESP, São Paulo, Brazil

Correspondence Address:
Dr. Morgana Arima Vedovato
Avenida Redenção, 465, Ap 113, Bairro Jardim Do Mar, São Bernardo Do Campo - São Paulo
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/PAJO.PAJO_45_20

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The two immunosuppressants most used topically in ophthalmology are cyclosporine (CS) and tacrolimus (TL). Their mechanism of action is similar, but the TL is ten to a hundred times more powerful than the CS. We reviewed the studies found in the literature on the use of topical TL and described them, as follows, divided by indication of use. Topical TL is effective and safe against inflammatory and immunological processes of the ocular surface, although it is less powerful than corticosteroids, it has fewer side effects.


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