Purpose: To report use of widefield fluorescein angiography (FA) for targeted therapy of Coats' disease and familial exudative vitreoretinopathy (FEVR). Study design: Retrospective, non-comparative, consecutive case series. Material and Methods: Patients diagnosed with Coats' disease or FEVR and evaluated with widefield FA, treated with indirect laser from January 1, 2003 to December 31, 2012. Visual acuity (VA) and anatomic status of eyes was evaluated. Results: 17 eyes were treated for Coats' disease, and 25 eyes treated for FEVR. Mean VA in the Coats' group was 20/384 at baseline, and mean VA at the last follow-up was 20/258. In the FEVR group, mean VA was 20/100 at baseline, and 20/358 at last follow-up. None of the Coats' eyes required enucleation or additional surgical intervention. Two of the eyes with FEVR required surgery due to advanced disease. Conclusion: Widefield angiographyguided laser therapy in Coats' disease and FEVR led to visual and anatomic stability in these diseases.

Background: Ophthalmology is the most technologydriven specialty among all the medical specialties. Advances in retinal imaging have proven fundamental to many paradigm shifts in our understanding and treatment of ocular disease. Methods: Literature review. Discussion: This article provides an overview of current, state-of-the-art retinal imaging technologies, as well as highlights many emerging imaging technologies that we believe are likely to transform the provision of eye care. Conclusions: The second decade of the 21st century is an exciting time to be an ophthalmologist, and especially a retinal specialist. However, studies of diagnostic accuracy are more prone to bias than many other forms of clinical research. With the likely imminent proliferation of ocular imaging techniques, standardized and robust methods for their clinical validation will be essential, with reporting of results according to standards for reporting of diagnostic accuracy recommendations.