Purpose: Normal-tension glaucoma has been associated with systemic vascular diseases such as peripheral vasospasm. This study aims to evaluate the influence of peripheral vasospasm on the thickness of the retinal nerve fiber layer (RNFL) in Raynaud's disease (RD), and the correlation between global RNFL and peripheral microcirculation features in RD patients. Methods: Observational cross-sectional study of 18 patients (35 eyes) with a diagnosis of RD followed in our clinic, and 20 healthy controls (39 eyes). RNFL parameters were obtained using spectral domain optical coherence tomography (SD-OCT Spectralis®, Heidelberg). Global and sectorial peripapillary RNFL thickness were registered. Age, gender, refractive error, best-corrected visual acuity and intraocular pressure were determined, and slit-lamp biomicroscopy and fundus examination were performed. Nailfold videocapillaroscopy (NC) was performed in the RD group to characterize capillary morphology and blood flow. Mann-Whitney and Fisher's exact tests were used for statistical analysis. Statistical significance level was set at p<0.05 (two-sided). Results: There was no significant difference in the global RNFL between RD patients and the control group (p=0.35). The presence of avascular areas in NC was associated with a lower global RNFL thickness (p=0.026). Conclusion: The association between avascular areas in NC and the lower global RNFL thickness in RD patients suggests that systemic vasospasm severity may be related to optic nerve damage propensity. Therefore, its presence in NC may identify RD patients at risk for optic nerve head damage. A larger sample with a long-term study is needed to support the clinical and therapeutic implications of our findings.

Purpose: To compare biometrical measurements performed with the new IOLMaster-700 (Carl Zeiss Meditec AG, Jena, Germany) from those obtained with the Aladdin (Topcon, Tokyo, Japan). Methods: A prospective, cross-sectional, observational, comparative study was proposed. Twenty-four eyes were assessed using two biometry devices. Measurements of axial length (AL), anterior chamber depth (ACD), mean keratometry (KM), flattest (Kf) and steepest keratometry (Ks) and white-to-white (WTW) were done with both devices in a random order. Results: No statistically significant differences (p>0.05) between the two biometry were found for AL (24.22±0.92mm [range 22.66 to 26.09 mm] with IOL Master and 24.22±0.91mm [range 22.65 to 26.09 mm] with the Aladdin), ACD (3.59±0.26mm [range 3.05 to 4.11 mm] with IOL Master and 3.42±0.60mm [range 3.05 to 4.02 mm] with the Aladdin) and Kf (42.43±1.21 D [range 40.55 to 45.15 D] with IOL Master and 42.41±1.25 D [range 40.66 to 45.36 D] with the Aladdin). In Km (42.99±1.23 D [range 41.07 to 45.31 D] with IOL Master and 42.90±1.27 D [range 41.06 to 45.55 D] with the Aladdin), Ks (43.55±1.38 D [range 41.20 to 46.57 D] with IOL Master and 43.40±1.42 D [range 41.21 to 46.62 D] with the Aladdin) and WTW (12.32±0.40mm [range 11.6 to 13.1 mm] with IOL Master and 12.03±0.36 mm [range 11.46 to 12.87 mm] with the Aladdin), there was a statistical difference. Conclusions: Measurements with the new IOLMaster-700 correlated well with those obtained with the Aladdin in patients with clear lens; although a statistical difference was found in KM, Ks and WTW. This difference was not clinically significant.