Year : 2021 | Volume
: 3 | Issue : 1 | Page : 14-
High risk of intraocular pressure rise with difluprednate post collagen cross-linking for keratoconus
Sofia Ramos Bartolomei, Lilia Rivera Román
Department of Ophthalmology, University of Puerto Rico, San Juan, Puerto Rico
Purpose: To report intraocular pressure (IOP) after use of difluprednate ophthalmic solution 0.05% (Durezol®; Novartis AG, Basilea, Switzerland) post corneal cross-linking (CXL) versus prednisolone (Pred-Forte®; Allergan Inc., Irvine, CA, USA).
Methods: A retrospective single-center case series evaluation of 34 keratoconus patients ages 16-“41 (36 eyes) who underwent CXL with Avedro's KXL System® (Avedro Inc; Waltham, MA) between August 2016 and August 2017. Post-CXL, six eyes were given difluprednate and 30 were given prednisolone. IOP was recorded using Reichert model 30 pneumatonometer. Those that exhibited increased IOP at 3 days were given anti-glaucoma medications and changed to fluorometholone or loteprednol.
Results: IOP's 3 days' postoperative (24.167 ± 5.23) in the difluprednate group were significantly higher than preprocedure (16.5 ± 2.258). In the prednisolone group, 3 days postprocedure the mean IOP (14.2 ± 3.199) was not significantly higher than preoperatory IOP mean (16.8 ± 4.232). The difference between IOP 3 days' postprocedure and before was 7.667 ± 4.546 for the difluprednate group and 2.567 ± 2.648 for the prednisolone group. These were compared using an unpaired t-test (t value = 3.750 ± 1.297) with P = 0.0007.
Discussion: This study shows statistically significant difference in postoperative and preoperative IOP values after the use of difluprednate or prednisolone in young patients postCXL. Measuring the pachymetry on follow-up examinations could help see if changes in corneal thickness affect measured IOP. A controlled prospective double-blind study could confirm a greater increase in IOP following difluprednate versus prednisolone use, but due to the high risk, we do not recommend this study.
Dr. Sofia Ramos Bartolomei
18 Calle Tintillo, Tintillo Gardens, Guaynabo 00966
|How to cite this article:|
Bartolomei SR, Román LR. High risk of intraocular pressure rise with difluprednate post collagen cross-linking for keratoconus.Pan Am J Ophthalmol 2021;3:14-14
|How to cite this URL:|
Bartolomei SR, Román LR. High risk of intraocular pressure rise with difluprednate post collagen cross-linking for keratoconus. Pan Am J Ophthalmol [serial online] 2021 [cited 2021 Apr 21 ];3:14-14
Available from: https://www.thepajo.org/article.asp?issn=2666-4909;year=2021;volume=3;issue=1;spage=14;epage=14;aulast=Bartolomei;type=0